Comparison of Curcumin and Amoxicillin trihydrate Incorporated onto Guided Tissue Regeneration Membrane against Porphyromonasgingivalis: An In vitro Study

Abstract

Background:

Guided Tissue Regeneration (GTR) is a effective periodontal treatment modality for regeneration, but it is able to be colonised by bacteria. Recently, attention has been drawn to the conflict between using conventional antibiotics and antimicrobial compounds generated from plants.

Aim:

The current study aimed to evaluate the antimicrobial activity of 1% Amoxicillin and 1% Curcumin loaded onto a GTR membrane against Porphyromonas gingivalis in vitro.

Methodology:

To dilute the concentrations to 1% Amoxicillin and 1% Curcumin, an appropriate amount of distilled water was used. Normal saline used as a negative control, and the GTR membrane was a sterile reconstituted Type-I collagen membrane. Membrane was soaked in the diluted solution. The antibacterial efficacy of GTR membrane coated with 1% Amoxicillin solution and 1% Curcumin solution was evaluated in vitro using the agar disc diffusion method.

Results:

The zone of inhibiton for GTR membranes treated with 1% Amoxicillin solution  showed antibacterial activity against Porphyromonasgingivalis.whereas 1% Curcumin solution and saline showed no zone of inhibition.Hence  amoxicillin exhibited effective antimicrobial action.

Conclusion:

Loading Amoxicillin onto the GTR membrane can help to prevent bacterial colonisation and improve treatment outcomes.